Help file generation for framework 2.0
I wrote a while back on available tools for generating help file for your .Net application, and recommended using the Sandcastle Help file builder (last updated on 01/2008). It a GUI wrapper for the Microsoft Sandcastle document compiler.
You also need to enable xml documentation file creation in your project properties. and there are further instructions in a Codeproject article (which may also be a bit outdated).
Seems the situation is about the same almost a year later: NDoc is dead, NDoc05 was last updated during 2006, and Quick Doc viewer hasn't been updated for a while.