influenced by Scott Hanselman's post here is my list of podcasts
Alt.NET Podcast
It’s a cool program with nice topics though it’s not published regular.
8/10 for presentation
8/10 for content
7/10 for audio quality
7/10 iPod integration
5/10 for persistence.
Stack overflow
Jeff Atwood & Joel Spolsky ramble on , it’s cool when you have the time.
8/10 for presentation
8/10 for content
9/10 for audio quality
7/10 iPod integration
10/10 for persistence.
The Flex Show
It’s the only Flex development oriented show I found. it’s nice but If you know a better one – please let me know.
6/10 for presentation
6/10 for content
7/10 for audio quality
6/10 iPod integration
9/10 for persistence.
Hanselminutes
Excellent show it began as 20 minute show and lately doubled in time it’s must for developers who strive for improvement
10/10 for presentation
10/10 for content
10/10 for audio quality
7/10 iPod integration
9/10 for persistence.
Manager Tools
it’s not software oriented , but more carrier oriented. I’m not sure what to say about this one
sometimes it sounds too much sleazy.
17/10 for presentation
7/10 for content
8/10 for audio quality
7/10 iPod integration
10/10 for persistence.
.NET Rocks!
As the name implies , .NET oriented show it’s must for .net developers
10/10 for presentation
9/10 for content
10/10 for audio quality
7/10 iPod integration
10/10 for persistence , two shows each week.
Software Engineering Radio
Platform agnostic show on a wide range of software engineering topics , about an hour in length.
8/10 for presentation
8/10 for content
8/10 for audio quality
5/10 iPod integration
10/10 for persistence , exactly every 10 days.
Sparkling Client
short and concise, 2- 10 minutes episodes on practical techniques in Silverlight development.
10/10 for presentation
8/10 for content
10/10 for audio quality
8/10 iPod integration
7/10 for persistence , the episode rate is irregular.
Thoughtworks - IT Matters 
Really cool and professional podcast , when these guys do something they do it well.
what can I say the show is hosted by Martin Fowler!
10/10 for presentation
10/10 for content
10/10 for audio quality
10/10 iPod integration (they have album covers + chapters !!)
2/10 for persistence – they haven’t published since July 08.
Making History עושים היסטוריה
פודקאסט עברי – על ההסטוריה של המדע והטכנולוגיה מוגש ע”י רן לוי
9/10 for presentation
10/10 for content
10/10 for audio quality
7/10 iPod integration
10/10 for persistence .